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#32, 7th A Main Road, Muthyalanagar, Mathikere,Bengaluru, Karnataka - 560054

// Life Science

Life Sciences

The life sciences or biological sciences research comprises the study/research of life and organisms like microorganisms, plants and animals including human beings. Life sciences discoveries are helpful in improving the quality and standard of life, and have applications in health, agriculture, medicine, and the pharmaceutical and food science industries.

Some of the areas where we can provide services and equipment are:

  1. Synthesizers: DNA, RNA, Oligo, Peptide synthesizers.

  2. Microscopy and Imaging: AFM for life science applications.

  3. Diffractometer: Single crystal XRD for protein and small molecule crystallography.

 

Products:

  1. DNA RNA Oligo synthesizer.

  2. Oligo Purifiers

  3. Cleavage Oven

  4. Peptide synthesizers.

  5. Automated In-situ hybridization (ISH) and Immuno hystochemistry (IHC) Robots.

  6. Automated protein digestion.

  7. Custom Peptide Services.

Intavis, Germany

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Founded in December 2000 INTAVIS Bioanalytical Instruments AG is leading company in developing, manufacturing and distributing systems to automate complex protocols in biochemistry and molecular biology. They have experience in instrument and method development in the automation of high throughput techniques such as functional genomics, proteome analysis and metabolism studies.

Intavis Product range and services include:

  • Automated In-situ Hybridization (ISH) and Immuno-Histochemistry (IHC) Robots: In situ hybridization (ISH), allowing the detection of DNA or RNA (mRNA, miRNA) and immuno-histochemistry (IHC) for detecting proteins and other antigens, are powerful techniques to explore the temporal and spatial expression pattern of genes and the localization of their products within organisms.

 

https://intavis.com/products/automated-in-situ-hybridization-and-immunohistochemistry/

The main models include InsituPro VSi fully automates all steps of these methods, thus allowing the user to concentrate on other scientific challenges. The BioLane HTI 16Vx is an economic solution that automates most steps and saves precious time. Both instruments are used by research groups worldwide for a large variety of organisms such as mouse, zebrafish, chicken, Xenopus, Drosophila, Arabidopsis and many more.

  • Automated Peptide Synthesis: The MultiPep RSi, MultiPep CF and Respep SLi are fully automated parallel peptide synthesizers. Exchangeable modules cover synthesis scales for screening with hundreds of peptides in parallel, the affordable production of specialty peptides in mini-columns or plates to the large scale synthesis of 300 mg peptide or more in column modules with agitation and heating options.

 

https://intavis.com/products/automated-peptide-synthesis/

  • Automated Protein Digestion: Protein digestion is an essential step in protein analysis that must be automated for high reproducibility and sensitivity. The DigestPro MSi completely automates in gel or in solution digestion procedures including reduction, alkylation, silver reduction and all washing steps. Furthermore, the peptide solutions can automatically be desalted and concentrated on ZipTips® or similar reverse phase tips. Finally, the samples can be spotted on a MALDI target plate or transferred to autosampler vials for LC-MS.

 

https://intavis.com/products/automated-protein-digestion/

  • Custom Peptide Services: Intavis manufactures high quality custom peptide tailored for particular needs! With strong roots in the scientific area and long-time experience in peptide synthesis, Intavis supports you in areas like signal transduction, proteomics, epigenetics, immunology (e.g. epitope mapping) and many more.

https://intavis.com/products/custom-peptide-services/

K & A Laborgerate, Germany

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K & A with more than 20 years of experience offers DNA/RNA/Oligo synthesizers and the complementary OPC purification and cleavage systems. 

 

K & A makes wide range of models, where low consumption, short cycle times, flexibility, simple handling and maintenance of the instruments are trademarks of K & A systems.

 

Long oligos of highest purity produced with K & A devices are superior compared to others. Wobbles, modifications and automated synthesis of S-oligos belong to the standard package as well.

 

K & A column synthesizers are the most modern on the world market. Single syntheses can be started and removed individually and independently from the state of process.

 

Furthermore, the online trityl monitor indicates quality of the running synthesis at all times.

 

Additionally, K & A provide custom development of synthesizers.  Resulting from many experience in operation oligo facility and in inspiring exchange of ideas with our customers during years of excellent relationship, K & A offers also complete oligo production lines, starting from sequence entry through synthesis, cleavage, purification, quality control and ending on the final paper work.

DNA/RNA/Oligo synthesizers 

K & A manufactures wide range of models based number of synthesis columns, amedite positions etc.  Typical models include H6, H8, H16 and H32 etc., indicating 6 or 8 or 16 or 32 columns. All these come on-line trytyl monitor. For price and less budget customers K & A offers S4 and S8 modela without on-line trytyl monitors.

Oligo purifiers 

Two different kinds of RP-purifiers: the small P-8 purifier for the H-8 synthesizers; semi manual easy controlled handling high quality of purification.

The big automated microplate P-96/P192 purifier for H-192, H-32 synthesizers and H-8 synthesizer production lines.

Before purifying the cleavage step will be made in our cleavage oven.

Cleavage Oven

  • Temperature                    programmable, up to 85 °C

  • Time:                            programmable, 1min – 99 hours

  • Shake speed:                programmable, 1 – 5 rotations/sec

  • Loading:                      56 single vials or one 96-microplate

CSInstruments, France

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Imaging life science samples pose many challenges because, samples have to be in their native environments (physiological) otherwise tissues and cells will die. Imaging AFM using AFM sharp tip also poses big problems.

CS Instruments also known as Concept Scientfic Instruments based in France is important designer and manufacturer of Atomic Force Microscope more popularly known as simply AFMs. Scanning Probe Microscope (SPMs) is more wider name includes all sharp tip based probing and imaging systems.

NanoObserver 

Well-known AFM mode with many applications and different modes. In life science applications AFM is implemented with Liquid cell and temperature to simulate physiological conditions.

https://www.csinstruments.eu/portfolio/life-science/

See some interesting AFM images:

Bacterias, Oscillating mode, 8µm

DNA, oscillating mode, 800nm

STOE, Germany

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STOE was established in 1887, they are one of the longest surviving XRD Company globally. STOE makes both powder XRD and single crystal XRD.

Single Crystal XRD

Unparalleled reliability, built to serve all scientific needs: e.g. small molecules, proteins, electron density measurements. Full accessibility of the sample environment for easy adaptation of high and low temperature attachments as well as high pressure cells.

IPDS II

STOE IPDS II: State of the art diffractometer with extremely sensitive and reliable imaging plate technology.

Features:

  • One single instrument for small molecules & proteins

  • Very high dynamic range (16 bits)

  • Extremely low background (no dark current)

  • Perfect for weak scatterers

  • Reliable intensities of very weak and very strong reflexions within the same frame

  • Long lifetime, low maintenance, low costs of ownership

IPDS IIT

STOE’s IPDS 2T combines all the achievements of the IPDS II with the possibility to turn the whole goniometer around the Θ axis to an angle of up to 60° yielding a 2Θmax of 137°! This additional axis makes the IPDS 2T a diffractometer of unique versatility. Featuring also the dual beam capability for using two different wavelengths on the same instrument the structure solution of small molecules and proteins as well as electron density determination and powder investigations are no challenge for the IPDS 2T.

Features

  • One single instrument for small molecules, proteins

  • Perfect for weak scatterers

  • Reliable intensities of very weak and very strong reflexions within the same frame

  • Long lifetime, low maintenance, low costs of ownership

  • Extend the features of IPDSII by collecting data up to 137° in 2θ

  • Useful for Co-radiation and electron density measurements

STOE STADIVARI

STOE STADIVARI The fastest and most flexible way to explore reciprocal space.

With the possibility to be set-up vertically as well as horizontally, the STADIVARI increases its scope of application.

 

The STADIVARI can be used for single crystal and powder diffraction. The Open Eulerian Cradle offers enough space to add high pressure cells, high- or low- temperature devices or other chambers.

 

In the dual beam setup, all combinations of tubes and microfocus BDS are possible: two sealed tubes, one sealed tube and one microfocus BDS or two microfocus BDS.

As the youngest member of the long line of STOE diffractometers, the STADIVARI is fully integrated in the well-established STOE X-Area software package.

Features

  • Flexible goniometer (Eulerian cradle and various fixed chi setups)

  • Sphere of confusion

  • State of the art interface

  • Various sources (Standard sealed tubes, Microfocus, MetalJet or synchroton)

  • Ultrafast hybrid pixel detector